1. Introduction Barakat Syndrome, also known as HDR Syndrome (Hypoparathyroidism, Deafness, and Renal Disease), is a rare genetic disorder characterized by a triad of symptoms—underactive parathyroid glands leading to hypocalcemia, sensorineural deafness, and renal abnormalities. The condition is typically caused by mutations in the GATA3 gene, which plays a crucial role in embryonic...